Abstract
The effect of removal of the thymus (Tx) from female Wistar rats at birth on the initiation of follicular growth in the rat ovary is reported. The thymus gland was removed within 12 hours of birth. Tx and sham-Tx were killed at operation and at 10 21 30 40 50 and 130 days after birth. The size and composition of the follicle population was quantitated in each ovary. The removal of the thymus gland at birth disrupts the size distribution and number of ovarian follicles by the 10th day of life. At 130 days ovarian dysgenesis is seen. From birth until 50 days of age the effects of removal of the thymus are reflected in the number of primordial follicles and follicles in the initial preantral growth stages. It is suggested that ovarian failure is initiated during the first 2 weeks of life in thymectomized rats.
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