Abstract
Reactive oxygen species are implicated as mediators of tissue damage in the acute renal failure induced by inorganic mercury. Astaxanthin (ASX), a carotenoid with potent antioxidant properties, exists naturally in various plants, algae, and seafoods. This paper evaluated the ability of ASX to prevent HgCl 2 nephrotoxicity. Rats were injected with HgCl 2 (0 or 5 mg/kg b.w., sc) 6 h after ASX had been administered (0, 10, 25, or 50 mg/kg, by gavage) and were killed 12 h after HgCl 2 exposure. Although ASX prevented the increase of lipid and protein oxidation and attenuated histopathological changes caused by HgCl 2 in kidney, it did not prevent creatinine increase in plasma and δ-aminolevulinic acid dehydratase inhibition induced by HgCl 2. Glutathione peroxidase and catalase activities were enhanced, while superoxide dismutase activity was depressed in HgCl 2-treated rats when compared to control and these effects were prevented by ASX. Our results indicate that ASX could have a beneficial role against HgCl 2 toxicity by preventing lipid and protein oxidation, changes in the activity of antioxidant enzymes and histopathological changes.
Published Version
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