Effect of Aspirin on Reproductive Functions in Male Albino Rats

Abstract

Summary: Palm wine is the sap of a monocarpic crop, Rafia rafia, which is widely grown along the coast of West and Central Africa. Several studies have been reported on the effects of palm wine on fetal cerebral cortex, but due to scanty information on its effects on androgenical studies, reproduction. These studies were designed to investigate the effects of palm wine on testosterone levels and reproductive parameters in Wistar albino rats. Fresh 50% diluted palm wine was administered orally for 30 days for reproductive studies at the dose of 10 mL/kg BW. Distilled water (0.5 mL) served as control. Testosterone level was assayed using ELISA, semen analysis were done microscopically. Histological analysis of the testis, kidney and liver were also done. Data were analysed using Students’ t-test at p 0.05) increase in body weights of treated rats relative to control. Palm wine (10 mL/kg BW) caused significant decrease in testosterone level (0.12±0.02 ng/ml; relative to control 1.38±0.52 ng/mL). Palm wine (10 mL /kg BW) caused significant decrease in sperm counts, motility and viability, but no significant change in morphology. There were interstistial congestion and odema of the testes. These findings probably indicate that palm wine caused deleterious effects on the reproductive parameters in male albino rats.