Abstract
The effect of Ashwagandharishta on the lipid profile and chronic toxicity of both male and female Albino rats were observed for 51 days. Our results demonstrate that the treatment of the plant extract failed to exhibit any statistically significant change (increase/ decrease) in the serum cholesterol (Total), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride of the male rats. But the female rats showed highly (p<0.01) and very highly (p<0.001) significant decrease in the serum cholesterol (Total) levels of the medium and high dose treated groups respectively. Regarding HDL, ASG showed statistically significant decrease at low (p <0.05), medium (p<0.01) and high (p<0.001) dose treated female rats. The LDL level of the medium dose treated female rats were statistically significant (p <0.05). The serum Triglyceride decreased significantly at low (p<0.01) and high (p <0.05) dose treated female rats.
 Jahangirnagar University J. Biol. Sci. 9(1 & 2): 59-68, 2020 (June & December)
Highlights
The effect of Ashwagandharishta on the lipid profile and chronic toxicity of both male and female Albino rats were observed for 51 days
Experimental Animals: Albino rats (Rattus novergicus : Sprague-Dawley strain, 48 weeks old, 70-80 g) of both sexes bred and maintained at the animal house of the Department of Pharmacy, Jahangirnagar University, were used in this toxicological experiment. They were kept in a well-ventilated hygienic experimental animal house under constant environmental and adequate nutritional conditions throughout the period of the experiment. They were fed with rat chow which was prepared according to the formula developed by Bangladesh Council of Scientific and Industrial Research (BCSIR)
Acute toxicity study: When the rats were treated with a high dose of Ashwagandharishta (4000 mg/kg body weight), the mortality rate was found to be zero
Summary
The effect of Ashwagandharishta on the lipid profile and chronic toxicity of both male and female Albino rats were observed for 51 days. Chronic toxicity study Effect of ASG on Serum Cholesterol (Total) level of male & female rat: All the doses of ASG showed no statistically significant increase or decrease in serum Cholesterol (Total) level of the male rats. In case of female rat, the medium and high dose results of ASG showed highly and very highly statistically significant decrease respectively in serum Cholesterol (Total) level at medium dose (18.107 %**) and high dose (24.306 %***).
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