Abstract
The effect of L-ascorbic acid (1) and related compounds on the growth of the tobacco hornworm, Manduca sexta Johannson, was determined. The dietary level of 1 necessary for normal development was 0.5 mM. Magnesium 2-O-phosphono-~-ascorbate, sodium 6-O-myristoyl-~-ascorbate, and L-dehydroascorbic acid were equally potent as 1. In contrast, analogues such as D-ascorbic acid, 6-bromo-6-deoxy-~-ascorbic acid, and D-isoascorbic acid were approximately one-half, one-fifth, and one-tenth as effective. Potassium 2-O-sulfato-~-ascorbate, L-isoascorbic acid, reductic acid, L-gluconic acid y-lactone, piperidinohexose reductone, dimethylaminohexose reductone, a-tocopherol acetate, p-hydroquinone, pyrocatechol, 2,3-dihydroxy-1,4-dithiobutane, sodium dithionite, and ferrous sulfate were at most only one-twentieth as active as 1.
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