Abstract
Liver cancer is an aggressive disease with a poor outcome. Here, we implicate the roles of arsenic trioxide (As2O3) and Ginsenoside Rg3 (GRg3) in VX2 carcinoma model of rabbits through CD31 and vascular endothelial growth factor (VEGF). Rabbits VX2 liver cancer models were established, then 24 rabbits were randomly divided into 3 groups with the same number (As2O3, GRg3 and control). Liver function and the levels of VEGF and CD31 were assessed. The tumor weight and levels of VEGF and CD31 in As2O3 and GRg3-treated rabbits were lower than those in controls, while no significant differences between As2O3 and GRg3 groups. There was no significant difference in the liver function among the groups. In conclusion, our findings implicate decreases in the tumor weight and the levels of VEGF and CD31 in the rabbits VX2 liver cancer induced by As2O3 and GRg3, while no significant differences between As2O3 and GRg3. GRg3 might be much more convenient than As2O3 in clinical application.
Highlights
Liver cancer is an aggressive disease with a poor outcome
We investigated the roles of As2O3 and GRg3 in VX2 carcinoma model of rabbits through CD31 and vascular endothelial growth factor (VEGF)
As2O3 and GRg3 down-regulated VEGF VEGF plays a key role in the formation and growth of normal blood vessels and in tumor angiogenesis [6]
Summary
Liver cancer is an aggressive disease with a poor outcome. Nowadays, increasing attention has been paid to the treatment of neoplasm angiogenesis [1], besides traditional surgery, radiotherapy, and chemotherapy, especially the use of traditional Chinese medicine. As2O3 and GRg3 play an important role in tumor angiogenesis inhibition. Few studies have explored the differences between As2O3 and GRg3 on liver cancer [2]. There was a positive correlation between microvessel density and tumor recurrence or survival. Various immunohistochemical markers were used to estimate microvessel proliferation in tumors, such as pan-endothelial markers CD31 [3] and antibodies against angiogenic proteins like vascular endothelial growth factor (VEGF) [4]. We investigated the roles of As2O3 and GRg3 in VX2 carcinoma model of rabbits through CD31 and VEGF
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