Abstract
The purpose of this study was to investigate the effect of hydroalcoholic extract of Artemisia persica (100, 200 and 400 mg/kg) on pentylenetetrazole-induced seizure and memory impairment. Sixty mice were assigned to seven groups. Pentylenetetrazole (35 mg/kg) was injected at 48 hours intervals for 9 days, and at 60 mg/kg on day 10 to induce seizure model. Different doses of A. persica extract were injected daily 30 min before pentylenetetrazole injection. Exposure of mice to extract significantly reduced the frequency of repeated spinning and jumping and tonic seizures in seizure model. In addition, the extract significantly reduced the increased levels of malondialdehyde in serum and brain. The extract significantly increased the serum and brain anti-oxidant capacity but had no significant effect on nitric oxide. The extract (100 mg/kg) significantly improved pentylenetetrazole-induced memory impairment. The hydro-alcoholic extract of A. persica has a protective effect against pentylenetrazole-induced seizure.
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Highlights
Epilepsy is a common neurological disorder characterized by unexpected and periodic seizures
The results of this study showed that A. persica extract had strong DPPH free radicals (IC50=80.98 μg/ mL) scavenging activity, moderate ABTS (IC50=29.55 μg/mL) and hydroxyl (IC50=600.09 μg/mL) free radicals scavenging activity, relatively good iron ion chelating activity (IC50=89.53 μg/mL), and strong ferric ion reducing activity
Seizure latency in the groups receiving the A. persica extract and the group receiving 400 mg/kg of this extract and flumazenil was not significantly different compared to that in the pentylenetetrazole group, but seizure latency was significantly higher in the group receiving 400 mg/ kg of the A. persica extract and diazepam than in the pentylenetetrazole group (p
Summary
Epilepsy is a common neurological disorder characterized by unexpected and periodic seizures. It will be essential to pay attention to traditional medicine and herbal medicines to achieve low-risk drugs with minimal side effects (Rostampour et al, 2014). The plants such as Aitchisonia rosea (Rasool et al, 2015), Bacopa monnieri (Paulose et al, 2008), Cannabis sativa (Leite and Carlini, 1973), Cyperus articulates (Bakanova and Leutskií, 2971), Sechium edule (Mumtaz et al, 2012), Silybum marianum (Waqar et al, 2016) and Zizyphus jujube (Puhaja et al, 2011) showed antiepileptic effect
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