Abstract
In the present study, the antigenotoxic effect of Artemisia herba-alba was evaluated against the genotoxic effect induced by 10 μM of ethinylestradiol in the presence of metabolic activation using mitotic index (MI), chromosomal aberrations, sister chromatid exchanges and replication index (RI) as parameters. The treatment of 10 μM of ethinylestradiol along with 102, 212.5, 315 and 417μg/mL of Artemisia albaextract in culture medium resulted in a significant dose dependent decrease in the genotoxic effects induced by the treatment of 10 μM of ethinylestradiol. The results of the present study suggest that the plant extract per se does not have genotoxic potential, but can modulate the genotoxicity of ethinylestradiol in cultured human lymphocytes. Key words: Artemisia alba, Methyltestosterone, ethinylestradiol, human lymphocytes, genotoxicity, natural products, chromosomal aberrations, sister chromatid exchanges.
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