Abstract
The effect of arsenic trioxide along with tannic acid, di-sodium hydrogen phosphate (DSHP), alum and effects of sand-charcoal-iron-filter (SCIF)-bed filtrated water along with alum on body weight and some hematological parameters were carried out on a total of 30 (01 month old) adult Newzealand white rabbits. The Rabbits were randomly divided in to 6 equal groups (A,B,C,D,E & F) at the ratio of three males and two females in each group, rats of group A was kept as control without giving any treatment, rabbits of group B received arsenic trioxide@100 ppm, group C received arsenic trioxide @ 100 ppm plus tannic acid @100 ppm, group D received arsenic trioxide @ 100 ppm plus di-sodium hydrogen phosphate @100 ppm, group E received arsenic trioxide @100 ppm plus alum @100 ppm orally daily for 60 days in all cases and group F received alum @100 ppm in SCIF-bed filtrated water orally daily for 60 days. The result showed that body weight gain of control group (A) per week per rabbit was found to increase but in treated group B (arsenic trioxide@100ppm orally daily) the mean body weight of group B were decreased gradually and significant (P<0.05) decrease in body weight was observed at 40 days of feeding and at day 60 it was highly significant (P<0.01). Rabbits of group C, D and E were apparently normal and mild body weight reductions were observed which was statistically insignificant. No body weight loss was observed in rabbit of group F. TEC, Hb and PCV were slightly reduced in group C, D, E and F but highly significant (P< 0.01) reduction of TEC, Hb and PCV were observed in group B. ESR values were slightly increased in group C, D, E and F but highly significant (P< 0.01) increased of ESR value was observed in group B. Leukocytosis was observed in rabbits of group B. In this study, it was concluded that treatment with arsenic oxide at low doses has harmful effects on experimental animals including hematological alterations.Asian J. Med. Biol. Res. March 2016, 2(1): 38-47
Highlights
Arsenic (As) is ―The Silent killer‖ for Bangladesh at present
In Bangladesh there is no available data in this context, so this research work has been carried out to study the effect of arsenic trioxide along with tannic acid, di-sodium hydrogen phosphate (DSHP), alum and effects of SCIF-bed filtrated water along with alum on body weight and some hematological parameters in rabbit
Hematological parameters Total erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content, erythrocyte sedimentation rate (ESR), packed cell volume (PCV) were determined as per methods cited by Coffin (1955)
Summary
Arsenic (As) is ―The Silent killer‖ for Bangladesh at present. In world water day 1998 arsenic marked as the king of poisons. Arsenic remains one of the most important carcinogens and diabetogenics in human (Eisler, 1988; Biswas et al, 2000; Mukherjee et al, 2004; Rana et al, 2010) Nowadays it is, after lead considered the most common toxic heavy metal affecting domestic animals (Selby et al, 1977; Doyle & Spaulding, 1978; Bazargani et al, 2007). Chronic poisoning causes ill thrift, weakness and inability, milk reduction and abortion (Selby et al, 1977; Bazargani et al, 2007; Radostits et al, 2007) Presence of this metal in water has been reported from different countries such as USA, Canada, Mexico, Argentina, Chile, Poland, Japan, China, Taiwan, Nepal, Vietnam, Bangladesh, India and Iran (Wang et al, 2002; Mandal & Suzuki, 2002; Ng et al, 2003; Hosseinpourfeizi et al, 2007; Mosaferi et al, 2008;). In Bangladesh there is no available data in this context, so this research work has been carried out to study the effect of arsenic trioxide along with tannic acid, DSHP, alum and effects of SCIF-bed filtrated water along with alum on body weight and some hematological parameters in rabbit
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