Effect of arrest time on the hemodynamic efficacy of precordial compression: Crit Care Med 1995; 23/7: 1233–1236

Abstract

Objectives : To evaluate the efficacy of conventional threshold levels of coronary perfusion pressure and end-tidal CO 2 as predictors of resuscitability after prolonged cardiac arrest. Design : Prospective, randomized, controlled animal study. Setting : University research laboratory. Subjects : Twenty-one Sprague-Dawley rats, including three groups of seven animals in each group. Interventions : Ventricular fibrillation was untreated for 9, 12, or 15 mins. After an additional 5-min interval of precordial compression, external direct current defibrillation was attempted. Measurements and Main Results : All animals were successfully resuscitated after 9 mins of ventricular fibrillation but less than one half of the animals were successfully resuscitated after 15 mins of ventricular fibrillation. Each of seven animals survived for 24 hrs after 9 mins of untreated ventricular fibrillation but none of the animals survived after 15 mins of ventricular fibrillation. In this experimental setting, neither coronary perfusion pressure nor end-tidal CO 2 produced by precordial compression was predictive of outcomes when the animals underwent progressively longer intervals of untreated cardiac arrest. Conclusions : The efficacy of precordial compression-as measured by coronary perfusion pressure and end-tidal CO 2 concentration after prolongation of untreated cardiac arrest- was not overtly compromised. However, the previously established critical threshold levels of coronary perfusion pressure and end-tidal CO 2 failed as predictors of resuscitability after prolonged intervals of untreated cardiac arrest. (Crit Care Med 1995 ; 23 :1233-1236)