Abstract
Purpose:To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats.Methods:We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, hematology and histopathology were used to validate the treatments.Results:All animals survived. A gradual weight gain in all groups was observed, with no significant difference (p>0.05). The oral administration of ACE and ACE+vincristine 50% significantly reduced breast tumors incidence examined with PET-18FDG and fluorescence (p<0.001). Significant reduction of serum transaminases, oxidative stress and hematological toxicity were observed in these groups. Antioxidant enzyme levels in breast tissue were significantly higher compared to the DMBA and DMBA+vincristine groups.Conclusion:These results demonstrate for the first time that ACE positively influences the treatment of DMBA-induced breast cancer in animal model, inducing a reduction in oxidative stress and chemotherapy toxicity, meaning that ACE may have clinical implication in further studies.
Highlights
Breast cancer is a major cause of morbidity and mortality among women
Based on data described above, the present study aimed to investigate whether A. chica extract (ACE) can attenuate the development of breast carcinoma and evaluate its antitumor effect when associated with half the dose of vincristine against induced-breast carcinoma by DMBA in rats
The standardized uptake values (SUV) of these images confirmed the rare presence of breast cancer, as a result of significant reduction in tumor uptake of 18-FDG and respective metabolic activity, as clearly visualized by microPET
Summary
Breast cancer is a major cause of morbidity and mortality among women. Worldwide, it is the second most common type of cancer. There is a tendency for increased mortality from breast cancer in Brazilian women[1]. Breast cancer originates from breast tissue, most commonly from the inner lining of milk ducts or lobes that supply the ducts, and the main metastasis pathway is the lymphatic system or the bloodstream[2]. Breast cancer may be induced by 7,12-dimethyl-1,2-benzanthracene (DMBA), a procarcinogen with selectivity for female breast cancer. It undergoes metabolic activation to carcinogenic dihydrodiolepoxide. Dihydrodiolepoxide binds to adenine residues of deoxyribonucleic acid, resulting in mutagenesis and carcinogenesis[3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
