Abstract
Objective: Tuberculosis (TB) is the threatful infectious disease that dwell about one third of worlds. Among Middle East, Iraq occupy the fifth order country endemic with TB. Methodology: Six mixtures of Argan oil: 1.5% H2O2 were prepared at different ratio: 1=0.75:9.25, 2=1:9, 3=1.5:8.5, 4=2:8, 5=2.5:7.5, 6=3:7 and mixed with Lowenstein-Jensen (L-J) medium. Seventeen Mycobacterium tuberculosis isolates got from the consultants clinic of respiratory and thoracic diseases in Hilla city-Iraq. All isolates cultured on LJ medium containing the mixture of Argan oil: 1.5% H2O2 in different ratio and control tube (LJ without mixture) also used. The growth monitored per a day and recorded at different interval and the inhibition (no growth) were recorded. Results: The effect of Argan oil: 1.5% H2O2 mixture on the Mycobacterium tuberculosis were investigated over three incubation intervals (14th -20th, 21st -28th and after 29th day). The results revealed the high Argan concentration mixture 2.5:7.5 and 3:7 give excellent inhibitory effect on Mycobacterium tuberculosis during full periods of incubation with inhibition percentage (64.71%-82.35%). Conclusion: The current study aims to investigate the effects of argan oil on Mycobacterium tuberculosis and conclude the anti-mycobacterial activity of argan oil as a safe medication for prophylaxis and treatment of TB.
Highlights
One third of the world’s population infected with Mycobacterium tuberculosis
The current study aims to investigate the effects of argan oil on Mycobacterium tuberculosis and conclude the anti-mycobacterial activity of argan oil as a safe medication for prophylaxis and treatment of TB
Tuberculosis still the major public health problem and emergence of multi-drug resistance TB (MDR-TB) and extensive drug resistance TB (XDR-TB) among M. tuberculosis(resistance to first and second line drugs respectively) push the scientist to investigate the effects of many oils and plant extract as alternative medications [8]
Summary
One third of the world’s population infected with Mycobacterium tuberculosis. It is the principal causative agent of the widespread disease, tuberculosis (TB), among human’s beings. WHO and Ministry of Health of Iraq (MOH) record that the incidence rate of TB decreased after during the period from 20112014, the incidence rate is 45 case for 100,000 people (from 2005-2010 the is incidence rate 64 case for 100,000 people) [5,6]. Malnutrition person and those with low socio-economic status are targeted by TB and the main strategies to compact this devil can be achieved via good nutrition and high level of personal hygiene [7]. In 2013 approximately 5% of patients infected with TB develop MDR-TB and about 9% of that MDR-TB has XDR-TB [9]
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