Abstract
In this paper, we synthesized titanium oxide films using unbalanced magnetron sputtering and etched subsequently the surface of the Ti–O films by Ar plasma to obtain different surface morphology. The surface characteristics of the etched Ti–O films were investigated using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Atom force microscopy (AFM). The wettability of etched Ti–O film was measured by a contact angle method. The biological behavior of cultured human umbilical vein endothelial cells (HUVECs) onto Ti–O film surfaces was evaluated by the in vitro HUVECs cultured experiment. The analysis results of film surface characteristics indicated that the structure of Ti–O film was uninfluenced after being etched by Ar plasma, but the composition of films were changed from nonstoichiometric to stoichiometric due to etching process, and the surface roughness of Ti–O films was decreased after being etched. Investigation on ECs cultured on Ti–O film surfaces shows that the etched Ti–O film surface could be accepted by ECs in a survival period, and the biological behavior of ECs was significantly varied as the Ti–O film surfaces etched in different degree. The adherence, growth and proliferation of HUVECs are in good state on stoichiometric TiO 2 film surface with a certain range of roughness, and proper wettability. The work indicated that the etched Ti–O film surfaces with certain characteristics are helpful for seeding ECs. Furthermore, the biocompatibility mechanism of ECs on films based on the relationship between the Ti–O film characteristics and biological behavior of ECs is preliminarily analyzed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
