Abstract
The main purpose of this research is to evaluate the high level of thyroxine affects on each of the luteinizing hormone (LH), testosterone, follicle-stimulating hormone (FSH) of rats and to estimate the potential effect of the administration of aqueous rosemary extract and propylthiouracil against testicular toxicity induced by levothyroxine in male rats. Negative control group rats were treated with distilled water. Three groups of male rats were treated subcutaneously with 0.5 mg/kg levothyroxine for 12 days: Since day 13th to the 24th day of the experiment first group was regarded as a positive control group that received distilled water, the second group was given propylthiouracil at a dose level of 10 mg/kg b.wt, and the third was given aqueous extracts of rosemary 10 mg/kg b.wt. The results revealed that treatment with aqueous extract of rosemary lead to a significant decrease in the levels of serum testosterone while a highly significant decrease in testosterone, FSH, and LH levels in serum revealed after treatment with propylthiouracil. Thus, it can be concluded that the effect of propylthiouracil and rosemary aqueous extract resulted in dialectical hormonal results in which the favor was to propylthiouracil.
Highlights
Levothyroxine (LT4), synthetic thyroxine administrated orally, is the favorable treatment for patients with hypothyroidism
The main purpose of this research is to evaluate the high level of thyroxine affects on each of the luteinizing hormone (LH), testosterone, follicle-stimulating hormone (FSH) of rats and to estimate the potential effect of the administration of aqueous rosemary extract and propylthiouracil against testicular toxicity induced by levothyroxine in male rats
The results revealed that treatment with aqueous extract of rosemary lead to a significant decrease in the levels of serum testosterone while a highly significant decrease in testosterone, FSH, and LH levels in serum revealed after treatment with propylthiouracil
Summary
Levothyroxine (LT4), synthetic thyroxine administrated orally, is the favorable treatment for patients with hypothyroidism. It could be administered for the repression of pituitary production of thyroid-stimulating hormone in cases of not poisonous multinodular goiter and diverse forms of neoplasia in thyroid [1]. Testosterone is the major secretive production of the testis, besides the 5a-dihydrotestosterone (DHT), 17-. It is testosterone that determines the former phase of testicular migration and the growth of male exterior genitalia [8]. FSH and LH are hormones of glycoprotein secreted from the pituitary gland which regulate growth, maturation, and roles of the gonad [9]
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