Abstract
Effect of Aqueous Extract of Liquorice (G. Glabra L) in Treatment of Stress Induced Gastric Ulcer in Wistar Rats
Highlights
AND REVIEW OF LITERATUREPeptic ulcer is a common ailment which has a prevalence rate of about 0.2% in the population worldwide
We evaluated the effect of water extract of Glycyrrhiza Glabra L, commonly known as Liquorice on stressinduced gastric inflammation
We found severe inflammatory changes in the mucosa of stomach among the rats exposed to immobilization stress
Summary
AND REVIEW OF LITERATUREPeptic ulcer is a common ailment which has a prevalence rate of about 0.2% in the population worldwide. Not a life-threatening disease, it causes undue distress and discomfort and accounts for increased time off from work thereby leading to manpower and economic losses. In this condition, histamine receptor blockers provide relief. Male Wistar rats (n=5 in each group) were procured from the central animal house and divided into four groups namely Group 1(control); Group 2 (low dose treatment); Group 3 (high dose treatment) and group 4 (prophylactic) They were housed individually and subjected to restraint stress in PVC pipes for 2 hours daily and their stomach was examined for ulcer in Licorice (oral) fed groups and control.
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