Abstract
Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice. A second tumour graft in tumour-bearing hamsters appeared more rapidly than the first. Prior administration of aprotinin abolished this effect. Pretreatment of non-cancerous mice with cortisone nullified the effectiveness of aprotinin in inhibiting the growth of a subsequent tumour graft. These results are interpreted as additional evidence that aprotinin enhances the immunological system against tumour cells.
Highlights
A second tumour graft in tumour-bearing hamsters appeared more rapidly than the first
To test the effect of aprotinin on immunological resistance to tumour cell growth using a fibrosarcoma in hamsters and an adenocarcinoma in mice
After saline administration the second tumotur graft appeared significantly earlier the first graft (P- 0005). This did not happen with the aprotinin treated animals (P > 0.05), and the second tumour graft took significantly longer to develop in the aprotinin group than in those receiving saline
Summary
Animals.-3-4-month-old inbred male Syrian hamsters and inbred female C3H mice (Heston specific) were used. Hamiister observations.-05 x 1O6 TRES cells in 0 5 ml medium 199 (Flow Laboratories Limited, Irvine, Ayrshire) were implanted s.e. into the left dorso-lumbar region of each hamster. One group was treated with 1 ml saline twice daily for 14 days, and the other with 1 ml aprotinin twice daily for the same length of time. After the treatment hald ended all animals were given another s.e. implant of 0-5 x 106 TRES cells; this time into the right scapula region. Mouse observations.-Two groups of mice (Group A and Group B) were treated with either 0-1 ml saline or 0-1 ml cortisone acetate respectively for 28 days. 0.5 ml SMA tumour (Latner et al, 1974) w%Aas implanted into the dorso-lumbar region of each mouse. The mice were left for one day, sacrificed, and each tumour dissected out to determine its wNet weight
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