Effect of Apium graveolens Extract Administration on the Pharmacokinetics of Captopril in the Plasma of Rats.

Siska Siska,Franciscus Suyatna,Abdul Mun`Im,Anton Bahtiar

doi:10.3390/scipharm86010006

Siska Siska, Franciscus Suyatna + Show 2 more

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https://doi.org/10.3390/scipharm86010006

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Abstract

Apium graveolens (celery) is an edible and traditionally medicinal plant that is used worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive drugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the study is to assess the effects of administrating the celery extract on captopril pharmacokinetics. Sprague-Dawley strain rats were divided into two groups (n = 6). Group I was given captopril (10 mg/kg Body Weight (BW)) orally, while Group II was pretreated with celery extract orally (40 mg/kg BW) an hour before administration of captopril. The blood samples were withdrawn at various intervals after drug administration. The captopril concentration was determined using liquid chromatography–mass spectrometry (LC-MS/MS) and from the blood data, the values of Ke, Cmax, Tmax, T1/2, and area under the curve (AUC) were calculated. The results showed that oral administration of the celery extract increased Cmax (38.67%), T1/2 (37.84%), and AUC (58.10%) and decreased Ke (27.45%) of captopril in Group II (celery + captopril) compared with Group I (captopril). In conclusion, celery extract can alter the pharmacokinetic of captopril when given in combination. The combination might be beneficial for the treatment of hypertension, as celery causes an increase in the plasma level of captopril, which can enhance its efficacy.

Highlights

Celery (Apium graveolens) is usually used in traditional medicine as a diuretic or anti-hypertensive agent
The mechanisms of drug interactions can be divided into several general categories, including pharmacokinetics and pharmacodynamics [3]
We aimed to study the interaction of celery with captopril to evaluate the pharmacokinetic interaction of captopril with celery using rat as the experimental animal model

Summary

Introduction

Celery (Apium graveolens) is usually used in traditional medicine as a diuretic or anti-hypertensive agent. It contains chemical compounds such as apiin, apigenin, isoquercitrin, and sesquiterpene [1,2]. Celery has been sold as food supplement, so the pharmaceutical industries do not need to prove the efficacy of the herbs or determine the side effects or interactions between the products [3]. Since herbs are widely available, people can use them alone or in combination with synthetic drugs. Combining synthetic drugs with herb preparations may have a synergistic effect or can increase the rate of side effects [4]

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