Effect of anxiety and depression on cardiopulmonary exercise test in patients with coronary artery disease.

Abstract

To compare the core indexes of cardiopulmonary exercise test (CPET) in the patients with coronary artery disease and combining anxiety and/or depression, and to explore the effect of the emotional disorder with "anxiety and/or depression" on cardiopulmonary function and exercise tolerance in patients with coronary artery disease. A total of 255 patients with stable coronary artery disease and 302 patients without coronary artery disease were selected as subjects. According to the results of anxiety and depression scale, they were divided into a control group (n=96), an anxiety group (n=35), a depression group (n=36), an anxiety and depression group (n=135), a coronary artery disease group (n=91), a coronary artery disease combined with anxiety group (n=35), a coronary artery disease combined with depression group (n=34) and a coronary artery disease combined with anxiety and depression group (n=95). The differences in the core indexes of CPET among the different groups were compared. Peak oxygen uptake, anaerobic domain, peak metabolic equivalent, and peak heart rate in all coronary artery disease groups were significantly lower than those in the control group, while peak systolic pressure and heart rate reserve were significantly increased (all P<0.05); among them, there were significantly difference in the above indexes between the coronary artery disease combined with anxiety and depression group and the coronary artery disease group (all P<0.05); there was no significant difference among the anxiety group, the depression group, and the anxiety and depression group and the control group (all P>0.05). The cardiopulmonary function and exercise tolerance is significantly decreased in the coronary artery disease combined with anxiety and depression patients; there is a declining trend in the cardiopulmonary function and exercise tolerance in the simple anxiety or simple depression patients. Simple anxiety, simple depression and simple anxiety combined with depression don't cause a negative impact on cardiopulmonary function and exercise tolerance in non-coronary artery disease control population.