Effect of anti-thyroid drug treatment duration and predictive for intraoperative blood loss in patients with Graves’ disease

Abstract

Background: Grave’s disease frequently results in and is the most common cause of hyperthyroidism. It also often results in an enlarged thyroid. It also known as toxic diffuse goitre, is an autoimmune disease that affects the thyroid. Objective: To evaluate all the factors that cause intra-operative blood loss and how it affects the grave’s disease. Methods: This study was conducted on 200 patients with Grave’s disease, who underwent thyroidectomy during the period from May 2010 to April 2016. For a period of 14 days, all patients were administered with potassium iodide before the surgery. Conventional open surgery or neck surgery video assisted were performed. SPSS (Version 22.0) was used for analysis. Results: The majority of patients were females which constitute about 76.3% with a median age of 32 years. The median period between the onset of the disease and operation was 15 months. Weight of thyroid in grams was 40. Post-operative hospital stay was 3 days. Univariate analysis revealed that the strongest correlation of amount of intraoperative blood loss (AIOBL) was noted with the weight of thyroid (p<0.001). Additionally, AIOBL was correlated positively with the period be- tween disease onset and surgery (p<0.001) and negatively with preoperative free T4 (p<0.01).