EFFECT OF ANTISEPTICS ON ATYPICAL REPRESENTATIVES OF ORAL MICROBIOTA IN WOMEN WITH BACTERIAL VAGINOSIS

Abstract

Introduction. The microflora of the human oral cavity is represented by more than 400 types of microorganisms. Cross-infection of open cavities of the human body leads to the appearance of atypical representatives, such as Gardnerella vaginalis and Atopobium vaginae, which are the causative agents of bacterial vaginosis. Objective. To compare the clinical effect of 0.2% chlorhexidine and 0.25% dequalinium chloride on Gardnerella vaginalis and Atopobium vaginae in the oral cavity of women suffering from bacterial vaginosis. Materials and methods. 40 women of childbearing age (18-45 years old) with clinically confirmed bacterial vaginosis were included in the study. The patients were divided into 2 groups of 20 women each, depending on the antiseptic used for the treatment of the oral cavity: the group I - 0.2% chlorhexidine, the group II - 0.25% dequalinium chloride. The patients were clinically examined before the start of the treatment and in 14 days after its completion. The examination included the determining Green-Vermilion index, PMA indices (in the Parma modification), complex periodontal index according to Leus (KPI), Pisarev-Shiller test, Svrakov number. The diagnosis is based on the classification of N.F. Danylevskyi (1994). Detection of Gardnerella vaginalis and Atopobium vaginae was carried out by the method of polymerase chain reaction. Results. After the treatment course, 75% of patients in the group I and 95% of women in the group II reported the disappearance of symptoms of bleeding, halitosis, and feeling of gum discomfort. The indicator of the RMA index in the group I was higher than the indicator in the II group by 7.89%. The difference between the indicators of the complex periodontal index according to Leus after treatment was 0.267 points. After the treatment course, Gardnerella vaginalis was detected by 15% less in patients of the group I compared to individuals of the group II; the similar situation was in terms of Atopobium vaginae, where the difference in indicators was identical to 15%. Conclusion. After the treatment completion, the indicators of the studied indices are lower in 1.2-1.6 times, the percentage of Gardnerella vaginalis and Atopobium vaginae detection is lower by 15%, compared to the standardized antiseptic, 0.2% chlorhexidine.