Abstract
A comparison was made of the properties of collagen isolated from the skins of rats treated with sodium salicylate, hydrocortisone, chloroquine and phenylbutazone respectively, and from skins of lathyric rats treated during the development of lathyrism with these anti-rheumatic drugs. The rate of reconstitution of fibrils from acid soluble collagen isolated from the lathyric group is inhibited. The dissolution of the collagen gel formed on incubation at 37° after subsequent cooling to 5° is increased. These manifestations of lathyrus toxicity did not occur in rats given either sodium salicylate, phenylbutazone and chloroquine at the same time or the lathyrogen. Administration of hydrocortisone with the lathyrogen affected the lathyric properties of collagen to a lesser extent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
