Abstract
Effect of Antimonial Therapy on Levels of (TNF-α and IL-1β;) Cytokines in Cutaneous Leishmaniasis Patients in Iraq
Highlights
Cutaneous leishmaniasis (CL) is a parasitic disease transmitted by sand flies and caused by obligate intramacrophage protozoa [1, 2]
Our main objective in this study was to understand the effects of antimonial compounds on the circulating levels of some proinflammatory cytokines, namely, interleukin1β, and tumor necrosis factor-alpha (TNF-α), before and during therapy for patients with CL
The results presented in this study were based on the analysis of a random sample of 50 cases with an established diagnosis of CL
Summary
Cutaneous leishmaniasis (CL) is a parasitic disease transmitted by sand flies and caused by obligate intramacrophage protozoa [1, 2]. Our main objective in this study was to understand the effects of antimonial compounds on the circulating levels of some proinflammatory cytokines, namely, interleukin1β, and tumor necrosis factor-alpha (TNF-α), before and during therapy for patients with CL. The results were in agreement with those reported by Al-Aubaidi [38] in Iraq and by Kocyigit [28] in Turkey, where they found circulating proinflammatory TNF-á cytokine levels increased in patients with CL.
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