Abstract
IF TECHNICAL error is excluded, tumors appear with consistent regularity in the laboratory rodent ovary when it is transplanted to the spleen of a castrate animal. This frequently confirmed response was first recorded by Biskind and Biskind (1), who suggested that tumors arise in ovaries transplanted to the spleen as a result of excessive and continuous gonadotrophic stimulation. In their opinion, enhanced gonadotrophic secretion follows hepatic inactivation of gonadal steroids which must pass through the liver en route to the general circulation from the ovarian implant in the spleen. The ensuing loss of the well-known inhibiting effect of ovarian hormones on the gonadotrophic secretions of the pituitary gland leads to exposure of the intrasplenic grafts to heightened gonadotrophic stimulation which eventually terminates in tumor formation. Support for the postulation of Biskind and Biskind has been derived from widely different experimental approaches. The literature has been summarized (3, 6, 7, 8).
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