Effect of Antifungal Drugs against Candida Isolates from Diabetic Women with Vaginitis

Abstract

Vaginitis is an inflammation of the vagina characterized by a whitish or whitish gray discharge, often with a curd-like appearance, odor, itching and irritation. Yeasts are always present in the vagina in small numbers, and symptoms only appear with overgrowth. The vaginal swab specimens were collected from the diabetic women with signs and symptoms of vaginitis. The isolated Candida species were identified by the morphological and cultural characteristics. The isolated and identified Candida strains were included C. albicans, C. dubliniensis, C. krusei, and C. tropicalis from diabetic women with signs and symptoms of vaginitis. The isolates were subjected to determine the in vitro anticandidal activity against antifungal drugs. All Candida strains isolated from diabetic women with vaginitis were 100% sensitive to Amphotericin-B and C. krusei strains showed 100% sensitivity to ketaconazole drug. Overall 32% of Candida strains showed multidrug resistance against the antifungal drugs we used.