Abstract
BackgroundAntiepileptic drug (AED) therapy is the main stay of treatment for most patients with epilepsy. These may cause various side effects like metabolic, biochemical and radiological abnormalities. The severity of bone and biochemical abnormalities is thought to correlate with the duration of AED exposure and the number of AEDs used.ObjectiveTo study the effect of AEDs on serum calcium levels in the epileptic patients and to compare any relationship of biochemical change with duration of therapy.Study designA case–control prospective study.Materials and methodsA total of 100 subjects presenting with epilepsy in the out-patient Department of Neurology of Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar, was selected. Fifty epileptic subjects taking AEDs for more than 6 months were considered as study group. These were again divided into two groups depending upon duration of treatment with AEDs taken.ResultsAEDs cause significant fall in serum calcium levels in epileptic patients and this fall is related to the duration of therapy.
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