Abstract
Background: Childhood epilepsy is one of the most common neurological disorders in pediatrics . The prevalence of active epilepsy is 5–8 per 1000 population in developed countries and 10 per 1000 population in developing nations . There is a significant relationship between epilepsy and cognitive deficits. Aim of study: prospective study to evaluate the effect of the most commonly used anti-epileptics drugs on plasma fibrinogen level. Patient and methods 100 newly diagnosed patients (2months to 15 years old) selected from Outpatient Clinic of Neurology attending Mansoura University Children’s Hospital for plasma fibrinogen level evaluation by taking basal sample and second sample after six months after the basal one. Results: This study showed that, significant positive correlation between plasma fibrinogen level and the use of antiepileptic drugs. Conclusion: epileptic patient should be closely monitored during Antiepileptic drugs treatment and prior to surgical procedures as they can affect plasma fibrinogen level and coagulation profile.
Highlights
Carbamazepine, phenytoin and valproic acid can cause thrombocytopenia, valproic acid and gabapentin have been associated with acquired von Willebrand disease type 1, hypofibrinogenemia,decreased factorXIII and abnormal platelet function
These children were reported with platelet dysfunction, thrombocytopenia, hypofibrinogenemia, acquired Von Wilbrand disease, Factor XIII deficiency and vitamin K-dependent factor deficiency (4)
Little is known about the hematological side effects of the newer antiepileptic drugs (AEDs), but recent case reports have raised concerns regarding the possibility of altered coagulation profile, thrombocyte counts or function in some patients during levetiracetam (LEV) treatment. .( 5) Carbmazepines have been reported to be associated with clotting defects including: elevated prothrombin time, elevated partial thromboplastin time, though the exact mechanism is not known yet (6)
Summary
Little is known about the hematological side effects of the newer antiepileptic drugs (AEDs), but recent case reports have raised concerns regarding the possibility of altered coagulation profile, thrombocyte counts or function in some patients during levetiracetam (LEV) treatment. Diagnosed Epileptic children by criteria of epilepsy , At least two unprovoked (or reflex) seizures occurring greater than 24 hours apart. Table (2) shows plasma fibrinogen in studied groups according to drugs used, there was statistical decrease in plasma fibrinogen level after 6 months of treatment when compared to initial plasma fibrinogen in groups treated with sodium valproate and groups treated with sodium valproate plus Topiramate .
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