Abstract
Penicillin, if injected into rats in large doses at different stages of pregnancy, had no adverse effect on the developing fetus or the newborn rat. Meanwhile benzathine penicillin (bicillin-3) caused resorption of the embryonic cells and acted adversely on development of the heart. Consequently, benzathine penicillin must not be used for the prevention of relapses of rheumatic fever on patients earlier than in the third trimester of pregnancy.
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