Effect of Anti-Infective Reconstituted Bone Xenograft Combined with External Fixator on Serum CRP and PCT Levels and Prognosis of Patients with Bone Infection after Lower Extremity Long Bone Trauma.

Fei Wang,Xiaofeng Qiu,Yang Liu,Wei Liu,Kun Yuan,Hao Fei,Songwen Tan

doi:10.1155/2021/5979514

Fei Wang, Xiaofeng Qiu + Show 5 more

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https://doi.org/10.1155/2021/5979514

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Abstract

Bone infection is one of the common complications of orthopedic surgery. After bone trauma occurs in the human body, the infection of Staphylococcus aureus and Gram-negative bacteria into the fracture area can lead to double infection of the soft tissue and bone tissue at the fracture site, leading to a variety of complications, mostly in the lower extremities. Bone infection easily causes bone destruction, bone nonunion, and bone defect, seriously affecting the quality of life of patients. The traditional treatment method of bone infection is to control the infection first and then repair the bone graft, but this method has a long course, poor efficacy, and high disability rate. In this study, anti-infective reconstituted bone xenograft (ARBX) combined with external fixation was used to treat patients with posttraumatic bone infections of the long bones of the lower extremities, to explore its efficacy, and to analyze its effects on serum CRP, PCT levels, and prognosis. Our results showed that ARBX combined with the external fixator had a good effect on the treatment of patients with bone infection after lower extremity long bone trauma, which could effectively enhance the repair and functional recovery of the limb bone, significantly alleviate the infection degree of patients, reduce the inflammatory response of the body, and have a good prognosis.

Highlights

Posttraumatic bone infection is one of the common serious complications after open fracture or orthopedic surgery open reduction, which is easy to cause bone destruction, bone nonunion, and fracture nonunion [1, 2]
The area of osteonecrosis is further expanded, which is easy to cause bone nonunion or bone defect, which seriously affects the quality of life of patients
For patients with severe bone infection, there will often be poor soft tissue coverage conditions, and the effect of internal fixation will be affected [11, 12]. erefore, the external fixator can be used to fix the patient, which is conducive to the treatment of bone infection. e purpose of this study was to explore the efficacy of Anti-infective reconstituted bone xenograft (ARBX) combined with external fixators in the treatment of patients with bone

Summary

Introduction

Posttraumatic bone infection is one of the common serious complications after open fracture or orthopedic surgery open reduction, which is easy to cause bone destruction, bone nonunion, and fracture nonunion [1, 2]. The area of osteonecrosis is further expanded, which is easy to cause bone nonunion or bone defect, which seriously affects the quality of life of patients. E traditional treatment method for chronic bone infection in clinical practice is to control the infection and repair the bone. For patients with severe bone infection, there will often be poor soft tissue coverage conditions, and the effect of internal fixation will be affected [11, 12]. Erefore, the external fixator can be used to fix the patient, which is conducive to the treatment of bone infection. E purpose of this study was to explore the efficacy of ARBX combined with external fixators in the treatment of patients with bone For patients with severe bone infection, there will often be poor soft tissue coverage conditions, and the effect of internal fixation will be affected [11, 12]. erefore, the external fixator can be used to fix the patient, which is conducive to the treatment of bone infection. e purpose of this study was to explore the efficacy of ARBX combined with external fixators in the treatment of patients with bone

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Results

Conclusion