Abstract
Objectives:To evaluate the outcome of anti-HP treatment on the nutritional status of children with Helicobacter pylori-positive gastritis.Methods:Sixty children with Helicobacter pylori-positive gastritis admitted to our hospital from June 2018 to June 2020 were selected as the experimental group, and 60 healthy normal people (Hp negative) were selected as the control group. The experimental group were given anti-HP treatment, and the improvement of their clinical symptoms after treatment and the changes of nutritional indexes such as hemoglobin and serum ferritin were observed one year after treatment. Gastroscopy was performed before treatment and four weeks after treatment, and the improvement of gastric inflammation and the positive rate of Hp were compared and analyzed before and after treatment.Results:The nutritional indicators of the children in experimental group were inferior compared with those in the control group (p<0.05). The clinical symptoms and signs of the experimental group were significantly alleviated after anti-Hp treatment, and the biochemical indicators were significantly improved after one Year of follow-up compared with those before treatment (p<0.05). The incidence of moderate and severe gastric mucosal inflammation in the experimental group decreased from 70% before treatment to 17% (p<0.05). The HP infection decreased from 100% before treatment to 13% (p<0.05).Conclusion:Helicobacter pylori infection has a negative impact on the nutritional status of children. Anti-HP therapy can improve the gastrointestinal symptoms and nutritional status of children, which plays an important role in the growth and development of children.
Highlights
Gastritis, as a common clinical disease of the digestive system in children, can lead to a series of complications such as water electrolyte disorder and malnutrition
Sixty cases of children with Helicobacter pyloripositive gastritis admitted to our hospital from June 2018 to June 2020 were selected as the experimental group, and 60 cases of healthy normal people (Hp negative) were selected as the control group
The comparative analysis of the nutritional indicators between the experimental group and the control group is shown in Table-I, indicating that the nutritional indicators of children in the experimental group were inferior to varying degrees compared with those in the healthy control group, and that the children with Hppositive gastritis had impaired nutritional status
Summary
As a common clinical disease of the digestive system in children, can lead to a series of complications such as water electrolyte disorder and malnutrition. With the continuous progress of examination technology and means, Helicobacter pylori (HP) infection has been found to be the main cause of gastritis in children.[1] HP is one of the more common pathogens in the human digestive system. About half of the world’s population is infected with HP, but only a portion of Hp infected individuals develop gastric and duodenal lesions. Pak J Med Sci September - October 2021 Vol 37 No 5 www.pjms.org.pk 1430. It is believed that the pathogenesis of Hp infection and disease outcomes is mediated by a complex interaction between host, environment and bacterial virulence factors.[2]
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