Effect of Anti-Diabetic Drugs on Vitamin B12 and Mineral Levels and their Role in Inflammation in type II Diabetes Mellitus (T2DM)

Abstract

Objectives: The purpose of the present study is to know the association between antidiabetic drugs and serum B12, and minerals like calcium, phosphorus, magnesium and zinc to understand their role in inflammation in type 2 diabetes mellitus. Methods: The sample size is 500 blood samples of both genders which was divided into 3 groups: A, B, and C. Group A on metformin of daily dosage 500mg consisted of 200 subjects, Group B on other anti-diabetic drugs of daily dosage 2 mg consisted of 200 subjects. Both groups A and B had no other complications from diabetes. Group C included controls, consisting of 100 healthy individuals with no history of diabetes. Findings: When compared between two drug(metformin and sulfonylureas) groups, the percentages of Serum B12, calcium, phosphorus, magnesium and zinc in both male and female groups were significantly decreased and consequently, inflammatory markers like leptin, IL-6, hsCRP, TNF-a were significantly increased in metformin group rather than who were on metformin and other associated drug group. Novelty : Decreased serum B12 levels in type 2 diabetes mellitus who are on metformin drug represents the potential trigger for inflammatory process which leads to micro and macrovascular complications when compared to sulfonylurea drug group. Keywords: Diabetes mellitus; Cobalamine; Calciumdependent process; Antioxidants; Inflammatory process