Effect of Angsana Bark Extract (Pterocarpus Indicus) on Re-Epithelialization in Experimental Rats (Sprague-Dawley) Incision Wound Model

Abstract

Injury is a damage to the continuity of body tissues or loss of epithelial makeup of the skin. One factor that can accelerate wound healing is treatment with antiseptics, including povidone iodine. Antiseptic ingredients in povidone iodine are known to be effective in killing microbes, but on the other hand the content of substances in this material can also cause irritation to wounds because of its irritative and toxic properties when used more than 10%. 1 Therefore, the use of herbal ingredients is one of the alternative treatments in the inflammatory process and wound healing because it is considered safer and has fewer side effects caused than non-herbal medicinal preparations. 2 It is known from several studies on angsana to contain active compounds that play a role in controlling inflammation and antibacterial that help the wound healing process. 3,4 In this study, an assessment was conducted on the effect of angsana bark extract (Pterocarpus indicus) on re-epithelialization in rat experimental animals (Sprague-Dawley) incision wound models. This research is an experimental laboratory research using the randomize controlled parallel method. The study was conducted with rats grouped into: groups given angsana bark extract (P1) consisting of 3 heads terminated on days 7 and 3 tails on day 14 and groups given povidone iodine (P2) consisting of 3 heads terminated on day 7 and 3 tails on day 14. Furthermore, rat skin tissue was made histological preparations with HE staining and re-epithelialization observations were made. The average measurement of re-epithelialization on day 7 was P1= 161.92 ?m, P2= 157.59 ?m and on day 14, P1=128.67 ?m, P2= 139.27 ?m with p>0.05 in each group. This showed that there was no significant difference in the two groups. So that angsana bark extract can be used as an alternative medicine for wound healing.