Abstract
The present investigation was undertaken to determine whether Ang-(1–7) is able to modify ATPase activities in membrane fractions prepared from several tissues. In the presence of 10 −6 M Ang-(1–7), total (Na +, K +, Mg 2+)-ATPase activity decreased 31% in rat atrium and 13% in sheep atrium but was unmodified in sheep liver, rat ventricle or crude brain membranes. In rat brain synaptosomal membranes, Ang-(1–7) at 10 −8 and 10 −7 M concentrations activated Na +, K +-ATPase 20 and 24%, respectively. Rat kidney Na +, K +-ATPase activity decreased roughly 40–70% with 10 −10–10 −6 M Ang-(1–7)), but increased 22% with 10 −12 M peptide concentration, thus indicating a biphasic effect. Our findings showing that ATPase from several tissues responds differently to Ang-(1–7) are attributable to enzyme tissue specificity.
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