Effect of anesthesia with sevoflurane on perioperative cTnI and CKMB in heart surgery of infants and children

Abstract

Objective To study the effect of anesthesia by inhalation of sevoflurane on perioperative cardiac troponin (cTnI) and creatine kinase MB (CKMB) in heart surgery of infants and children. Methods 40 infants and children were randomly and averagely divided into an observation group and a control group. The patients received repair of ventricular septal defect for congenital heart disease and were admitted by our hospital from May, 2014 to May, 2016.The observation group got anesthesia with sevoflurane, sufentanil, and rocuronium, while the control group with propofol, sufentanil, and rocuronium. After surgery, the differences in running time, aortic cross clamp time, re-beating, and cTnI and CKMB levels in each period were compared between these two groups. Results There were no statistical differences in running time, aortic cross clamp time, and re-beating between the two groups (all P>0.05). The decannulation time and ICU dead time of the observation group were significantly shorter than those of the control group, with statistical differences (all P<0.05). There were statistical differences in cTnI and CKMB levels in various stages between these two groups (all P<0.05). Conclusions The application of sevoflurane in anesthesia can reduce the perioperative cTnI and CKMB levels in heart surgery of infants and children and protect myocardial cells to some extent. Key words: Sevoflurane; Infants and children; Perioperative period; cTnI; CKMB