Abstract
The effects of the chronic administration of testosterone, androstenedione and DHA upon adrenal cortical function in the rat were compared. Only testosterone induced hypertensive disease and decreased 11β- and 18-hydroxylase activity in vitro. Significant decreases in adrenal mitochondrial cytochrome P-450 levels were apparent in all androgen-treated groups. Testosterone administration also resulted in a significant increment in the concentration of cytochromes a + a 3. The DOC-induced difference spectrum was reduced in all androgen-treated groups when expressed per mg of protein but only in mitochondria from testosterone-treated rats when calculated per nanomole of cytochrome P-450. The results suggest that the inhibition of the 11β- and 18-hydroxylation of DOC by testosterone is the result of competitive binding to cytochrome P-450 and not the induced decrease in cytochrome P-450 levels per se.
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