Abstract
The effect of Anderson localization in DNA on the Auger destruction by the Coulombic explosion at ionized radiation has been theoretically discussed in the present work. The theory of Auger destruction of DNA has been modified taking into account the localized and delocalized electron states in DNA owing to the correlated disorder in a sequence of nucleotides. According to the modified theoretical model of Auger destruction, the dominant ratio of delocalized states to localized states in exon compared to intron results in stronger radiation resistance of exons to ionized irradiation causing the Auger-cascade process than the radiation resistance of introns.
Highlights
DNA macromolecule is considered to be a long sequence of discrete site potentials-basic nucleotides
ISRN Biophysics between intercalated rhodium noncovalently bonded to the DNA duplex and the thymine dimer, but it diminished with disruption of the intervening π-stack
In this work we consider the dependence of bond break probability upon the electron localization lengths differing in coding and noncoding sequences at realization of Coulombic explosion at direct ionized irradiation of DNA
Summary
DNA macromolecule is considered to be a long sequence of discrete site potentials-basic nucleotides. Since most of the mutations in DNA are successfully healed, they assumed the existence of charge transport through delocalized states, responsible for the transfer of information at much longer distances.
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