Effect of an antioxidant inhibitor of the 3-hydroxypyridine class on immunocompetent and stem cells

Abstract

The effect of a synthetic antioxidant inhibitor belonging to the 3-hydroxypyridine class, compound OP-6, on functions of immunocompetent and stem cells was studied in mice. Models of synthesis of antibodies against sheep's red blood cells (local hemolysis and hemagglutination tests), endogenous and exogenous colony formation in (CBAxC57BL/6j)F1 mice and homografting CBA mice with skin from C57BL/6j donors were used. Compound OP-6 was shown to have an immunodepressive action on both humoral and cellular immunity, but it did not depress the colony-forming ability of the stem cells or protect them against the action of irradiation.