Abstract
(1) The effects of an ACTH 4–9 analog (Org 2766) on event related potentials, heart rate and response speed were investigated within a two-stimulus reaction time paradigm involving 200 trials. (2) Two groups of 16 male volunteers each received either 40 mg Org 2766 or placebo in a double-blind setting. (3) As compared to placebo controls, the subjects receiving Org 2766 showed (a) slower motor responses, (b) no decrease in the early component of slow cortical potentials across trials, (c) a smaller P300 amplitude, and (d) less pronounced decrease of mean heart rate across trials. This pattern of psychophysiological responses may be interpreted as reflecting peptide effects on attention: the ACTH 4–9 analog tends to facilitate attention directed to one set of stimuli but to impair a shift of attention between different attentional sets.
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