Effect of amphotericin B on the frog skin in vitro. Evidence for outward active potassium transport across the epithelium.

Abstract

AbstractIt is shown that amphotericin B (5×10‐5 M) increases the permeability of the frog skin to potassium, chloride and urea. The potassium flux was more strongly increased from the inside to the outside than from the outside to the inside of the skin, whereas the chloride and the urea fluxes were equally enhanced in both directions. The increased potassium flux from the inside to the outside could not be explained by a potassium loss from the cells. It is suggested that a part of the high outward potassium flux was due to an active outwards transport of potassium.