Abstract
Traditionally <i>Pterocarpus erinaceus</i> stem bark have being widely used in treatment of anemia. The goal of this examination is to explore the viability of <i>Pterocarpus erinaceus</i> stem bark removes on jungle fever initiated paleness. Anaemia was induced by inoculation of 2ml of infected blood containing 0.1 x 107 <i>Plasmodium beghei</i>. The sickly mice were treated with 250 and 500mg/body weight of watery and ethanolic concentrates of <i>Pterocarpus erinaceus</i> stem bark for four days. The results shows that there is significant (P>0.005) increase in both haematological parameters (PCV, Hb and RBC), haematological indices (MCV, MCH and MCHC) and immunological parameters (WBC, platelets, neutrophils and lymphocytes) in malaria control compared to normal. Oral administration of 250 and 500mg/kg body weight of aqueous and ethanolic extract of <i>Pterocarpus erinaceus</i> stem bark shows significant increase (p>0.05) in haematological parameters compared to malaria control. There were significant improvement in WBC, platelets, neutrophils, hympolytes and MCH. Compared to malaria control. The anaemic mice treated with 250/500mg/kg body weight of ethanolic extract showed significant improvement in both haematological and immunological parameters tested. These result suggest that <i>Pterocarpus erinaceus</i> stem bark can he used in managing anemia.
Highlights
Pterocarpus erinaceus stem bark have being widely used in treatment of anemia
Malaria is endemic in Nigeria with about 97% of the population at risk of infection sparing Sahel regions and high mountainous area of the Plateau
Plasmodium falciparum causes lysis of red blood cells or suppresses its production from bone marrow resulting in malarial anaemia [3]
Summary
Pterocarpus erinaceus stem bark have being widely used in treatment of anemia. Oral administration of 250 and 500mg/kg body weight of aqueous and ethanolic extract of Pterocarpus erinaceus stem bark shows significant increase (p>0.05) in haematological parameters compared to malaria control. The anaemic mice treated with 250/500mg/kg body weight of ethanolic extract showed significant improvement in both haematological and immunological parameters tested. These result suggest that Pterocarpus erinaceus stem bark can he used in managing anemia. Malaria is endemic in Nigeria with about 97% of the population at risk of infection sparing Sahel regions and high mountainous area of the Plateau It represent almost 110 million clinically analyzed cases for each annum, 60% of outpatient visits and 30% hospitalization. Phytochemicals and herbal products have proved effective in anaemic mice [5]
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