Abstract
Objective To explore the therapeutic effect of amoxicillin and clavulanate potassium combined with Bazhengsan on pediatric urinary tract infection (UTI). Methods The data of 120 UTI children treated in Wuhan Xinzhou District People's Hospital from February 2019 to February 2020 were retrospectively analyzed. They were equally split into experimental group (EG) and control group (CG) according to the order of admission. All children were treated with amoxicillin and clavulanate potassium for suspension (twice a day), and EG was additionally treated with one dose of Bazhengsan daily. Both groups were treated for 10 days. After treatment, the immune function indexes, inflammatory factor levels, and clinical efficacy were compared before and after treatment. Results No remarkable differences in the general data such as blood routine and urine routine results were observed between the two groups before treatment (P > 0.05). After treatment, EG achieved obviously better immune function indexes (P < 0.001) and lower levels of inflammatory factors (P < 0.05) compared with CG. Besides, the treatment effective rate in EG (96.7%) was higher than that in CG (P < 0.05). Conclusion Amoxicillin and clavulanate potassium combined with Bazhengsan can improve the immune function of UTI children and reduce the levels of inflammatory factors, with remarkable effects, which should be popularized in practice.
Highlights
Pediatric urinary tract infection (UTI) refers to urinary tract inflammation caused by pathogens invading urinary tract mucosa or tissue
Amoxicillin and clavulanate potassium is a mixture of the β-lactam antibiotic with the β-lactamase inhibitor, which can enhance the sensitivity of pathogens to amoxicillin and inhibit the production of drug-resistance bacteria [5]
Many reports have shown that amoxicillin and clavulanate potassium can reduce the clinical symptoms of UTI children, and especially oral administration of this drug can reduce the incidence of complications such as phlebitis, with definite efficacy [6, 7]
Summary
To explore the therapeutic effect of amoxicillin and clavulanate potassium combined with Bazhengsan on pediatric urinary tract infection (UTI). All children were treated with amoxicillin and clavulanate potassium for suspension (twice a day), and EG was treated with one dose of Bazhengsan daily. Both groups were treated for 10 days. The immune function indexes, inflammatory factor levels, and clinical efficacy were compared before and after treatment. EG achieved obviously better immune function indexes (P < 0.001) and lower levels of inflammatory factors (P < 0.05) compared with CG. Amoxicillin and clavulanate potassium combined with Bazhengsan can improve the immune function of UTI children and reduce the levels of inflammatory factors, with remarkable effects, which should be popularized in practice
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