EFFECT OF AMLODIPINE ON MONOSODIUM GLUTAMATE-INDUCED CARDIAC OXIDATIVE STRESS IN RATS

Abstract

Monosodium glutamate, MSG, induces oxidative stress which underlies many ailments including inflammation and heart dysfunctions. Amlodipine, AML, an anti-hypertensive could result to unknown effects on the cardiac oxidative function when co-taken with MSG. This study evaluated the effect of AML against experimental MSG-induced cardiac oxidative stress. Thus, rats orally and for 14 consecutive days received MSG (8000 mg/Kg/day). Cardiac oxidative stress bio-indicators: malondialdehyde, MDA, nitric oxide, NOX, glutathione peroxidase, GPX, superoxide dismutase, SOD, catalase, CAT, albumin, ALB, total protein, TP, magnesium, Mg, and zinc, Zn were determined. MSG significantly (p < 0.05) increased MDA and Zn but decreased others without altering NOX content compared to control rats in consistency with induction of cardiac oxidative stress in the rats. AML dose-dependently mitigated these MSG-induced oxidative effects. Thus, AML can protect against MSG-induced cardiac oxidative stress in the rats. Keywords: Monosodium glutamate, Amlodipine, Oxidative stress, Heart, Nitric oxide