Effect of Amlodipine drug on male sex hormones of hypertensive patients in Al-Najaf province

Abstract

The current study was carried out in Al-Sader teaching Hospital in Al-Najaf province during the period 2011/6/5 till 2011/12/2. The study was undertaken to evaluate the effect of Amlodipine drug that’s uses to treatment of hypertension on male sex hormones (LH ,FSH and testosterone) in a number of males hypertensive patients . Forty five males patients who are took this drug to lower their high blood pressure participated in the study , their ages ranged from (31-60) years divided into three groups (15 male/group) according to amlodipine doses 2.5, 5 and 10 mg once daily .Also contribute fifteen health males as a control subjects, their ages ranged from (30-63) years. Results of the study revealed a significant decreased of LH, FSH and testosterone activities in a patients who are treated with two highly doses of amlodipine when compared with control group, also when compared high dose group with low dose group. Regarding the effect of different ages of male hypertensive patients who are treated with amlodipine on these hormones , the findings were indicated a significant decreased of these hormones levels at the highest ages especially at 51-60 years old. On the other hand, the results obtained there were an effect of interaction between different doses of amlodipine and ages of hypertensive patients that treated with it on male sex hormones levels particularly at the higher doses and ages , and this effect was represented by decreased of these hormones levels. The study was suggested that the therapy with amlodipine may be causes defect in male reproductive system that indicated by inhibition of male sex hormones levels and this effect was amlodipine doses and patients' ages dependent.