Abstract
Aminophylline inhibited platelet aggregation in human platelet-rich plasma. This inhibition was reversed by adrenaline at concentrations of adrenaline insufficient to induce platelet aggregation. The action of adrenaline was inhibited by phentolamine but not by propranolol. Aminophylline had no effect on the release of adenine nucleotides or the breakdown of radioactively labelled ATP induced by thrombin in washed, isolated platelets. These results suggest that the mechanism of inhibition of platelet aggregation by aminophylline is unconnected with the platelet “release reaction”. The observed action of adrenaline suggests that agonists acting at alpha-adrenergic loci may lead to reduction in platelet cyclic AMP.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
