Effect of amino acid deficiency or excess on creatinine excretion of rats

Abstract

The effect of single amino acid deficiencies or excesses on urinary creatinine excretion was studied in rats fed an otherwise balanced amino-acid-containing diet. Omission of single amino acids generally decreased creatinine excretion significantly. Gelatin addition produced a relatively large increase in creatinine excretion, but additions of other amino acids in excess did not point to a consistent change in the excretion pattern; some led to an increased and some to a decreased excretion, and some had no effect. With the exception of the gelatin effect, none of the amino acid excesses led to changes in creatinine excretion of the magnitude or significance observed with the amino-acid-deficient diets.