Effect of Alumina Incorporation on the Surface Mineralization and Degradation of a Bioactive Glass (CaO-MgO-SiO₂-Na₂O-P₂O₅-CaF₂)-Glycerol Paste.

Dilshat Tulyaganov,Emanuel Ionescu,Mirabbos Hojamberdiev,Ralf Riedel,Olim Ruzimuradov,Khasan Abdukayumov

doi:10.3390/ma10111324

Dilshat Tulyaganov, Emanuel Ionescu + Show 4 more

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https://doi.org/10.3390/ma10111324

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Abstract

This study investigates the dissolution behavior as well as the surface biomineralization in simulated body fluid (SBF) of a paste composed of glycerol (gly) and a bioactive glass in the system CaO-MgO-SiO2-Na2O-P2O5-CaF2 (BG). The synthesis of the bioactive glass in an alumina crucible has been shown to significantly affect its bioactivity due to the incorporation of aluminum (ca. 1.3–1.4 wt %) into the glass network. Thus, the kinetics of the hydroxyapatite (HA) mineralization on the glass prepared in the alumina crucible was found to be slower than that reported for the same glass composition prepared in a Pt crucible. It is considered that the synthesis conditions lead to the incorporation of small amount of aluminum into the BG network and thus delay the HA mineralization. Interestingly, the BG-gly paste was shown to have significantly higher bioactivity than that of the as-prepared BG. Structural analysis of the paste indicate that glycerol chemically interacts with the glass surface and strongly alter the glass network architecture, thus generating a more depolymerized network, as well as an increased amount of silanol groups at the surface of the glass. In particular, BG-gly paste features early intermediate calcite precipitation during immersion in SBF, followed by hydroxyapatite formation after ca. seven days of SBF exposure; whereas the HA mineralization seems to be suppressed in BG, probably a consequence of the incorporation of aluminum into the glass network. The results obtained within the present study reveal the positive effect of using pastes based on bioactive glasses and organic carriers (here alcohols) which may be of interest not only due to their advantageous visco-elastic properties, but also due to the possibility of enhancing the glass bioactivity upon surface interactions with the organic carrier.

Highlights

The application of glasses as “biomaterials” has revolutionized the field of human biomedicine and has brought the concept of “surface active” materials which have the ability to elicit a special response on their surface when in contact with biological fluids [1,2]
In our previous study [9], BG melt glass was prepared in a Pt crucible and its bioactivity was studied upon simulated body fluid (SBF) exposure
The bioactivity of a melt glass prepared in alumina crucible (BG), as well as of a BG-glycerol paste, was investigated

Summary

Introduction

The application of glasses as “biomaterials” has revolutionized the field of human biomedicine and has brought the concept of “surface active” materials which have the ability to elicit a special response on their surface when in contact with biological fluids [1,2] It has been well accepted and agreed that the key feature which leads to the bone-bonding ability of bioactive glasses (and of bioactive materials in general), is the formation of hydroxycarbonate apatite (HCA) on their surface. This layer considerably enhances the interfacial adhesion of the implant to bone tissue and a stable interface is maintained long enough to favor further cellular interaction such as the incorporation. There has been an alternative opinion which considers the mineralization of HCA layer on the glass surface not critical for the bioactivity of the material [4], as the ionic dissolution products from the bioactive material appear to stimulate the growth and differentiation of cells at the genetic level, an effect which has been considered to be dose dependent

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