Abstract
The distribution of 99mTc sulfur colloid and 59Fe was assessed in rats following long or short term stimulation or suppression of erythropoiesis. Acute stimulation of erythropoiesis did not alter 99mTc sulfur colloid distribution, whereas, long term stimulation resulted in increased marrow colloid uptake. Suppression of erythropoiesis by hypoxia-induced plethora or hypertransfusion did not alter the marrow uptake of 99mTc sulfur colloid. 99mTc sulfur colloid blood clearance was not altered by any of the experimental conditions utilized. These observations suggest that marrow RE activity as assessed by 99mTc sulfur colloid uptake increases with erythropoietic stimulation and varies with the duration and intensity of the stimulus.
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