Abstract
BackgroundDiabetes mellitus is a heterogeneous metabolic disorders characterized by abnormally high levels of blood glucose The main objective of the present work is to study the effect of Alpinia calcarata on glucose uptake in streptozotocin (STZ) induced diabetic rats.MethodsThe diabetes was induced by single dose of STZ (45 mg/kg) in citrate buffer, while the normal control group was given the vehicle (citrate buffer) only. After induction of diabetes, the diabetic animals were treated with ethanolic extract of Alpinia calcarata (200 mg/kg) and glibenclamide (2 mg/kg) for 30 days. Blood glucose estimation was performed every week of the study. At the end of study period, animals were sacrificed for biochemical studies.ResultsStreptozotocin induced diabetic rats shows the altered levels of various biochemical profiles. Those levels were brought back to near normal upon treatment with ethanolic extract of Alpinia calcarata and standard drug glibanclamide. No significant changes were observed on treatment with plant extract alone group indicated that there are no toxic substances present in Alpinia calcarata. The antidiabetic activity of plant extract was also further confirmed by histopathological studies. The ethanolic extract of Alpinia calcarata shows significant inhibition of alpha glucosidase activity and also enhancing the glucose uptake in rat hemidiaphragm.ConclusionsIn conclusion, the ethanolic extract of Alpinia calcarata ameliorates the condition associated with diabetes.
Highlights
Diabetes mellitus is a heterogeneous metabolic disorders characterized by abnormally high levels of blood glucose
In the present study the activity of ethanolic extract of Alpinia calcarata rhizome was evaluated in streptozotocin induced diabetic rats
The effect of the ethanolic extract Alpinia calcarata on body weight in the STZ induced diabetic rats are shown in Figure 1, the results indicate that the body weight of the untreated diabetic rats was found to be significantly decreased when compared with the normal control group
Summary
Diabetes mellitus is a heterogeneous metabolic disorders characterized by abnormally high levels of blood glucose. Diabetes mellitus has been recognized as a growing world-wide epidemic by many health’s advocacy groups including the World Health Organization (WHO). It is a major public health problem affecting 285 million or 6.4% of the world populations for the year 2010, reported by International Diabetes Federation 2009. Insulin and other oral hypoglycemic drugs have characteristic profile of adverse effects. Diabetes mellitus is a heterogeneous metabolic disorders characterized by abnormally high levels of blood glucose The main objective of the present work is to study the effect of Alpinia calcarata on glucose uptake in streptozotocin (STZ) induced diabetic rats
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