Abstract
The patient of chronic arsenic toxicity shows oxidative stress. To overcome the oxidative stress, several antioxidants such as beta-carotene, ascorbic acid, alpha-tocopherol, zinc and selenium had been suggested in the treatment of chronic arsenic toxicity. In the present study universal anti-oxidant (both water and lipid soluble antioxidant) alpha-lipoic acid was used to examine the effectiveness of reducing the amount of arsenic from arsenic-loaded isolated liver tissues of rat. Isolated liver tissues of Long Evans Norwegian rats were cut into small pieces and incubated first in presence or absence of arsenic and then with different concentrations of alpha-lipoic acid during the second incubation. alpha-Lipoic acid decreases the amount of arsenic and malondialdehyde (MDA) in liver tissues as well as increases the reduced glutathione (GSH) level in dose dependent manner. These results suggest that ?-lipoic acid remove arsenic from arsenic-loaded isolated liver tissues of rat.
Highlights
IntroductionAbout half of the total populations (more than 50 millions) of Bangladesh, at present, are consuming arsenic through drinking and cooking (Misbahuddin, 2003; Mudur, 2000)
About half of the total populations of Bangladesh, at present, are consuming arsenic through drinking and cooking (Misbahuddin, 2003; Mudur, 2000)
Chemicals and reagents to measure lactase dehydrogenase (LDH) and total protein were from Human Gmbh (Germany). α-Lipoic acid was a gift from Opsonin Pharma Limited, Bangladesh
Summary
About half of the total populations (more than 50 millions) of Bangladesh, at present, are consuming arsenic through drinking and cooking (Misbahuddin, 2003; Mudur, 2000). The basic treatment is to stop drinking arsenic contaminated water and allow the patient to use arsenic-safe water (Smith et al, 2000). Some authors suggest the use of β-carotene, vitamin A, ascorbic acid, α-tocopherol, zinc, selenium and spirulina for the treatment of chronic arsenic toxicity (Ahmad et al, 1998; Misbahuddin et al, 2006). Duration of treatment ranges from 4-12 months. Prolong duration of treatment affects the patients’ compliance as well as treatment cost
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