Effect of Aloe vera on some serum bioactive parameters in male Wistar albino rats

Abstract

For centuries, Aloe vera has been hailed as a natural remedy with a plethora of health benefits. The present study aimed to evaluate the impact of A. vera on their haematological, biochemical, and immunological parameters. Twenty male Wistar albino rats were taken and split into two groups. Group I (Treatment Group)received a prepared aqueous A. vera extract at a concentration of 50 mg/kg of body weight for a full 30 days. Group II (Control Group) was given 0.9% normal saline as a placebo.The study found that the rats that received the A. vera extract had significantly (p<0.05) higher packed cell volume (14.8±1.08) compared to the control group (11.26±0.45). However, there were no significant changes in the levels of hemoglobin (Hb), red blood cell count (RBC),mean corpuscular hemoglobin (MCH) concentration, white blood cells (WBC) count, platelets count, and mean corpuscular volume (MCV). The serum alanine transaminase (ALT) concentration (U/L) was significantly (p<0.05) lower in the treated group (39.54±7.74) than in the control group (77.68±6.96), while there were no significant changes in the levels of urea and creatinine compared to the control group. The plasma levels of proinflammatory markers(TNFa, IL-6, and IFNγ) showed no significant differences between both groups. Overall, A. vera showed promise as a natural remedy for improving certain aspects of health, but more research is needed to understand its effects fully.