Abstract
The effect of alloxan on anion transport in isolated mouse liver mitochondria was studied with the swelling technique. Mitochondria pre-incubated with alloxan exhibited partial inhibition of the transport of malate, citrate, pyruvate and glutamate. 2n-butylmalonate caused complete inhibition of malate transport, and the translocation of citrate was completely blocked by 1,2,3-benzenetricarboxylate, while N-ethylmaleimide inhibited glutamate transport partially. The observation that alloxan inhibits different mitochondrial anion transport mechanisms emphasizes that the drug profoundly affects mitochondrial function.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
